VCP Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 10736-1-AP

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Freight/Packing

Con: 40 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
SH-SY5Y cells, HeLa cells, human brain tissue, MCF-7 cells, mouse brain tissue, mouse lung tissue, mouse thymus tissue, rat brain tissue, rat lung tissue

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human gliomas tissue, human colon cancer tissue, human gliomas tissue, human lung cancer tissue

Positive IF detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:100-1:400
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
valosin-containing protein

Calculated molecular weight:
89 kDa

Observed molecular weight:
90-100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
VCP

Synonyms
15S Mg(2+) ATPase p97 subunit, IBMPFD, p97, TER ATPase, TERA, valosin containing protein, VCP
Background

VCP(Valosin-containing protein), also known as TER ATPase and 15S Mg2+-ATPase p97 subunit, belongs to the AAA ATPase family. VCP was first identified as a result of attempts to clone a putative peptide hormone called valosin. It was found that the cloned cDNA encoded a ubiquitously expressed 90 kDa cytosolic protein, termed VCP, which showed none of the characteristics of a peptide hormone precursor(PMID:1382975). Defects in VCP are the cause of inclusion body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD) and amyotrophic lateral sclerosis type 14 with or without frontotemporal dementia (ALS14). VCP has a calculated molecular weight of 89 kDa and an apparent molecular weight of 90-100 kDa (PMID: 15732117, 1382975).


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