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VEGF Receptor 2 Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 26415-1-AP

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Con: 60 μg/150 μl

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Tested Applications

Applications:
WB, IHC, IF, FC, ELISA
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Images See all

VEGF Receptor 2 Antibody WB human placenta tissue 26415-1-AP

human placenta tissue were subjected to SDS PAGE followed by western blot with 26415-1-AP( VEGF Receptor 2 antibody at dilution of 1:600 incubated at room temperature for 1.5 hours

VEGF Receptor 2 Antibody IHC human oesophagus cancer tissue 26415-1-AP

Immunohistochemistry of paraffin-embedded human oesophagus cancer tissue slide using 26415-1-AP( VEGF Receptor 2 antibody at dilution of 1:200 (under 10x lens).

VEGF Receptor 2 Antibody IHC human oesophagus cancer tissue 26415-1-AP

Immunohistochemistry of paraffin-embedded human oesophagus cancer tissue slide using 26415-1-AP( VEGF Receptor 2 antibody at dilution of 1:200 (under 40x lens).

VEGF Receptor 2 Antibody FC HUVEC cells 26415-1-AP

1X10^6 HUVEC cells were stained with 0.2ug VEGF Receptor 2 antibody (26415-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.

Species specificity:
human, mouse, rat, sheep
Positive WB detected in:
human placenta tissue, mouse heart tissue
Positive IHC detected in:
human oesophagus cancer tissue, human lung cancer tissue, human colon cancer tissue, human liver cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive FC detected in:
HUVEC cells
Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
VEGF Receptor 2 fusion protein Ag24589
Full name:
kinase insert domain receptor (a type III receptor tyrosine kinase)
Calculated molecular weight:
1356aa,152 kDa
Observed molecular weight:
200 kDa
GenBank accession number:
BC131822
Gene ID (NCBI):
3791
Gene symbol
KDR
Synonyms
CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGF Receptor 2, VEGFR, VEGFR 2, VEGFR2

Background

KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.


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