VEGF Receptor 2 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 26415-1-AP

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Freight/Packing

Con: 60 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
human placenta tissue, mouse heart tissue

Positive IHC detected in:
human oesophagus cancer tissue,human lung cancer tissue, human colon cancer tissue

Positive FC detected in:
HUVEC cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
kinase insert domain receptor (a type III receptor tyrosine kinase)

Calculated molecular weight:
1356aa,152 kDa

Observed molecular weight:
200 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
KDR

Synonyms
CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGF Receptor 2, VEGFR, VEGFR 2, VEGFR2
Background

KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.


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