VNN1 Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 21745-1-AP

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Freight/Packing

Con: 56 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse kidney tissue, BxPC-3 cells, mouse kidney tissue, PC-13 cells

Positive IP detected in:
mouse kidney tissue

Positive IHC detected in:
human pancreas cancer tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
vanin 1

Calculated molecular weight:
513aa,57 kDa

Observed molecular weight:
55-72 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
VNN1

Synonyms
HDLCQ8, Pantetheinase, Pantetheine hydrolase, Tiff66, vanin 1, VNN1
Background

VNN1(Vascular non-inflammatory molecule 1) is also named as Vanin-1,Pantetheinase,Tiff66.It is a GPI-anchored 70-kDa protein with a high degree of homology with GPI-80 (also known as VNN2), a molecule expressed by human phagocytes and involved in leukocyte adhesion and migration.Vanin-1 is predominantly expressed by resident tissue cells and acts at the level of epithelial cells and surrounding hematopoietic cells by paracrine cysteamine release(PMID:17163446). The full length VNN1 has a signal peptide, a propeptide and six glycosylation sites. According to some authors, the variations which varied between 55 and 72kDa may be due to different degrees of glycosylation of the protein and cleavage(JOSE A et al. 2001).


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