VPS45 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 12006-1-AP

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Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive IHC detected in:
human gliomas tissue, human heart tissue, human testis tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
vacuolar protein sorting 45 homolog (S. cerevisiae)

Calculated molecular weight:
570aa,65 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
VPS45

Synonyms
h VPS45, H1, H1VPS45, hlVps45, VPS45, VPS45A, VPS45B, VPS54A, VSP45, VSP45A
Background

The Sec1/Munc18 (SM) family of proteins regulate intracellular trafficking through interactions with individual SNARE (soluble N-ethylmeleimide-sensitive factor attachment protein receptor) proteins and assembled SNARE complexes. The SM protein VPS45 (Vacuolar protein sorting-associated protein 45) has a calculated molecular mass of 65 kDa and shares 38% identity with yeast Vps45 which is required for the formation of yeast endosomal SNARE complexes and is thus essential for traffic through the endosomal system. VPS45 may play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network. (PMID: 8996080; 23166732)


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