XIAP Antibody 14 Publications

Rabbit Polyclonal| Catalog number: 10037-1-Ig

Featured Product KD/KO validated

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Freight/Packing

Con: 42 μg/150 μl

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Species specificity:
human, rat

Positive WB detected in:
HepG2 cells, C6 cells, COLO 320 cells, HeLa cells, Jurkat cells

Positive IHC detected in:
human pancreas cancer tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Protein A purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
X-linked inhibitor of apoptosis

Calculated molecular weight:
60 kDa

Observed molecular weight:
45-57 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
XIAP

Synonyms
API3, BIRC4, hIAP 3, hIAP3, hILP, IAP 3, IAP like protein, IAP3, ILP, ILP1, MIHA, X linked IAP, XIAP, XLP2
Background

XIAP, also named as API3, BIRC4 and IAP3, belongs to the IAP family. It has E3 ubiquitin-protein ligase activity. It mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. XIAP is an inhibitor of caspase-3, -7 and -9. It mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B. XIAP is an apoptotic suppressor. It is ubiquitinated and degraded by the proteasome in apoptotic cells. The MW of XIAP is 45-56 kDa.


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