ZBTB33 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 55270-1-AP

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Freight/Packing

Con: 65 μg/150 μl

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Species specificity:
human

Positive WB detected in:
A431 cells

Positive IP detected in:
A431 cells

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
zinc finger and BTB domain containing 33

Calculated molecular weight:
74 kDa

Observed molecular weight:
68-74 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ZBTB33

Synonyms
KAISO, ZBTB33, ZNF kaiso, ZNF348
Background

ZBTB33, also named as Transcriptional regulator Kaiso, is a 672 amino acid protein, which localizes in nucleus and cytoplasm. ZBTB33 as a transcriptional regulator with bimodal DNA-binding specificity binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). ZBTB33 recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters and may contribute to the repression of target genes of the Wnt signaling pathway. The calculated molecular weight of ZBTB33 is 75 kDa, but modified protein is about 100 kDa (PMID: 10207085 and PMID: 16354691)


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