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Recombinant human beta-NGF (Cat.NO. HZ-1222) stimulates proliferation of TF-1 cell line (human erythroleukemic cell line) in a dose-dependent manner (blue curve, refer to bottom X-left Y). The activity of human beta-NGF (2 ng/mL HZ-1222) is neutralized by mouse anti-human beta-NGF monoclonal antibody 69009-1-Ig at serial dose (red curve, refer to top X-right Y). The ND50 is typically 4-20 ng/mL
Beta nerve growth factor (NGF) is critical for the survival and maintenance of sympathetic and sensory neurons and may play an important role in the regulation of the immune system (PMID 16842161). The presence of beta NGF in immune cells, endocrine cells, and the CNS limbic areas suggests that beta NGF may function as an intracellular messenger to regulate the body’s response to stress (PMID 19442684). Xeno-free Recombinant Human beta NGF is expressed in human 293 cells as a non-disulfide bonded homodimeric protein with an apparent molecular mass of 13 kDa. This product is produced in a human cell expression system with serum-free, chemically defined media.
This antibody is used to Block/Neutralize Beta nerve growth factor protein.