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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human SCF

Activity

Typically ≤ 25 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1024

Synonyms

c Kit ligand, DKFZp686F2250, KIT ligand, Kitl, KITLG, KL 1, Mast cell growth factor, MGF, SCF, SF, SHEP7, Stem cell factor



Technical Specifications

GeneID 4254
Species human
Expression HEK293
Activity Typically ≤ 25 ng/mL EC50
Purity >95%
Molecular Mass 35 to 45 kDa, monomer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Product Description

Animal-free Recombinant Human SCF is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 35 to 45 kDa. This product is produced in a human cell expression system with serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications. SCF is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation, and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages.

Background

SCF is a hematopoietic growth factor that works by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation, and differentiation of hematopoietic cells (PMID: 12773427)

Synonyms

c Kit ligand, DKFZp686F2250, KIT ligand, Kitl, KITLG, KL 1, Mast cell growth factor, MGF, SCF, SF, SHEP7, Stem cell factor

Publications

SpeciesTitle
human

Haematologica

CD123 expression patterns and selective targeting with a CD123-specific antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia.

Authors - Evgeniya Angelova
human

Blood Res

Generation of hematopoietic stem cells from human embryonic stem cells using a defined, stepwise, serum-free, and serum replacement-free monolayer culture method.

Authors - So-JungKim
human

PLoS One

A synthetic model of human beta-thalassemia erythropoiesis using CD34+ cells from healthy adult donors.

Authors - Y TerryLee
human

J Tissue Eng Regen Med

Iron dose-dependent differentiation and enucleation of human erythroblasts in serum-free medium.

Authors - ColleenByrnes
human

Oncotarget

Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling.

Authors - JingLi
human

Stem Cells

Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines.

Authors - Niels-BjarneWoods