CD274 (PD-L1, B7-H1) Monoklonaler Antikörper

CD274 (PD-L1, B7-H1) Monoklonal Antikörper für FC

Wirt / Isotyp

Ratte / IgG2b, kappa

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

APC Fluorescent Dye

CloneNo.

10F.9G2

Kat-Nr. : APC-65073

Synonyme

B7 H1, Cd274, CD274 (PD-L1, B7-H1), CD274 antigen, PD L1, Pdcd1l1, Pdcd1lg1



Geprüfte Anwendungen

Erfolgreiche Detektion in FCAnti-CD3/CD28 treated 2 days BALB/C mouse splenocytes

Empfohlene Verdünnung

AnwendungVerdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

FCSee 1 publications below

Produktinformation

APC-65073 bindet in FC CD274 (PD-L1, B7-H1) und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Ratte / IgG2b, kappa
Klonalität Monoklonal
Typ Antikörper
Immunogen k.A.
Vollständiger Name CD274 antigen
GenBank-ZugangsnummerBC066841
Gene symbol Cd274
Gene ID (NCBI) 60533
Konjugation APC Fluorescent Dye
Excitation/Emission maxima wavelengths650 nm / 660 nm
Form Liquid
Reinigungsmethode Affinitätsreinigung
Lagerungspuffer Phosphatbasierter Puffer mit 0,09% Natriumazid und 0,1% Gelatine, pH 7,2.
LagerungsbedingungenStore at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

Programmed cell death ligand 1 (PD-L1, CD274, or B7-H1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested as a negative regulator of T and B cell, and plays important role in mediating tolerance of lymphocytes to self-antigens. It is also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PD-1-independent manner.

Protokolle

Produktspezifische Protokolle
FC protocol for APC CD274 (PD-L1, B7-H1) antibody APC-65073Protokoll herunterladen
Standard-Protokolle
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen

Publikationen

SpeciesApplicationTitle
FC

Cell Signal

Cancer-associated fibroblasts-induced remodeling of tumor immune microenvironment via Jagged1 in glioma

Authors - Qing Zhang