PD-L1/CD274 Monoklonaler Antikörper
PD-L1/CD274 Monoklonal Antikörper für FC
Wirt / Isotyp
Ratte / IgG2b, kappa
Getestete Reaktivität
Maus
Anwendung
FC
Konjugation
PE Fluorescent Dye
CloneNo.
10F.9G2
Kat-Nr. : PE-65073
Synonyme
Geprüfte Anwendungen
Erfolgreiche Detektion in FC | Anti-CD3/CD28 treated mouse splenocytes |
Empfohlene Verdünnung
Anwendung | Verdünnung |
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This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, check data in validation data gallery |
Veröffentlichte Anwendungen
FC | See 2 publications below |
Produktinformation
PE-65073 bindet in FC PD-L1/CD274 und zeigt Reaktivität mit Maus
Getestete Reaktivität | Maus |
In Publikationen genannte Reaktivität | Maus |
Wirt / Isotyp | Ratte / IgG2b, kappa |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | k.A. |
Vollständiger Name | CD274 antigen |
GenBank-Zugangsnummer | BC066841 |
Gene symbol | PD-L1 |
Gene ID (NCBI) | 60533 |
Konjugation | PE Fluorescent Dye |
Excitation/Emission maxima wavelengths | 496 nm, 565 nm / 578 nm |
Form | Liquid |
Reinigungsmethode | Affinitätsreinigung |
Lagerungspuffer | PBS with 0.09% sodium azide |
Lagerungsbedingungen | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
Hintergrundinformationen
Programmed cell death ligand 1 (PD-L1, CD274, or B7-H1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested as a negative regulator of T and B cell, and plays important role in mediating tolerance of lymphocytes to self-antigens. It is also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PD-1-independent manner.
Protokolle
PRODUKTSPEZIFISCHE PROTOKOLLE | |
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FC protocol for PE PD-L1/CD274 antibody PE-65073 | Download protocol |
STANDARD-PROTOKOLLE | |
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Klicken Sie hier, um unsere Standardprotokolle anzuzeigen |
Publikationen
Species | Application | Title |
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Biochem Pharmacol Targeting HMGA1 contributes to immunotherapy in aggressive breast cancer while suppressing EMT | ||