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- KD/KO Validated
CRBN Monoklonaler Antikörper
CRBN Monoklonal Antikörper für ELISA
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
Hausschwein, human, Maus
Anwendung
IHC, ELISA
Konjugation
Unkonjugiert
CloneNo.
2A9D11
Kat-Nr. : 66336-1-Ig
Synonyme
Galerie der Validierungsdaten
Geprüfte Anwendungen
Empfohlene Verdünnung
| Anwendung | Verdünnung |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Veröffentlichte Anwendungen
| IHC | See 1 publications below |
Produktinformation
66336-1-Ig bindet in IHC, ELISA CRBN und zeigt Reaktivität mit Hausschwein, human, Maus
| Getestete Reaktivität | Hausschwein, human, Maus |
| In Publikationen genannte Reaktivität | human |
| Wirt / Isotyp | Maus / IgG1 |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | CRBN fusion protein Ag17166 |
| Vollständiger Name | cereblon |
| Berechnetes Molekulargewicht | 442 aa, 51 kDa |
| Beobachtetes Molekulargewicht | 51-60 kDa |
| GenBank-Zugangsnummer | BC017419 |
| Gene symbol | CRBN |
| Gene ID (NCBI) | 51185 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3. |
| Lagerungsbedingungen | Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
CRBN plays an important role in assembly and surface expression of functional BK(Ca) channels. The mutation of human cereblon gene (CRBN) is related with mild mental retardation, and causes ARNSID (nonsyndromal intellectual disability) by distubing the developmental regulation of BK(Ca) in brain regions that are critical for memory and learning. CRBN is also identified as important thalidomide-binding protein for limb outgrowth in zebrafish and chicks. It can be detected a band above 51 kDa (maybe 55 kDa) in HT22 cells(PMID: 21232561).
Publikationen
| Species | Application | Title |
|---|---|---|
Front Oncol Prediction Model for Cereblon Expression in Bone Marrow Plasma Cells Based on Blood Markers in Multiple Myeloma Patients. |
Rezensionen
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
FH S (Verified Customer) (11-22-2021) | I couldn't get this antibody to work. In my blots (tried 2-3 times on HEK293T), there are so many bands both in Nu and Cy factions. Hard to tell which band is for CRBN.
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