CRBN Monoklonaler Antikörper

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• KD/KO Validated

CRBN Monoklonal Antikörper für ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

Hausschwein, human, Maus

Anwendung

IHC, ELISA

Konjugation

Unkonjugiert

Publikationen(1)

CloneNo.

2A9D11

Rezensionen (1)

Kat-Nr. : 66336-1-Ig

Synonyme

cereblon, CRBN, MRT2A, Protein cereblon

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Geprüfte Anwendungen

Veröffentlichte Anwendungen

• IHC: See 1 publications below

Produktinformation

66336-1-Ig bindet in IHC, ELISA CRBN und zeigt Reaktivität mit Hausschwein, human, Maus

• Getestete Reaktivität: Hausschwein, human, Maus
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Maus / IgG1
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: CRBN fusion protein Ag17166
• Vollständiger Name: cereblon
• Berechnetes Molekulargewicht: 442 aa, 51 kDa
• Beobachtetes Molekulargewicht: 51-60 kDa
• GenBank-Zugangsnummer: BC017419
• Gene symbol: CRBN
• Gene ID (NCBI): 51185
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-G-Reinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CRBN plays an important role in assembly and surface expression of functional BK(Ca) channels. The mutation of human cereblon gene (CRBN) is related with mild mental retardation, and causes ARNSID (nonsyndromal intellectual disability) by distubing the developmental regulation of BK(Ca) in brain regions that are critical for memory and learning. CRBN is also identified as important thalidomide-binding protein for limb outgrowth in zebrafish and chicks. It can be detected a band above 51 kDa (maybe 55 kDa) in HT22 cells(PMID: 21232561).

Publikationen

Species	Application	Title
human	IHC	Front Oncol; Prediction Model for Cereblon Expression in Bone Marrow Plasma Cells Based on Blood Markers in Multiple Myeloma Patients.; Authors - Byung-Hyun Lee

Rezensionen

The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.

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FH

S (Verified Customer) (11-22-2021)

I couldn't get this antibody to work. In my blots (tried 2-3 times on HEK293T), there are so many bands both in Nu and Cy factions. Hard to tell which band is for CRBN.

• Applications: Western Blot
• Primary Antibody Dilution: 1:1000
• Cell Tissue Type: HEK293T, HCT116

CRBN Antibody Western Blot validation (1:1000 dilution) in HEK293T, HCT116 (Cat no:66336-1-Ig)