SLC4A7/NBCn1 Recombinant monoclonal antibody, PBS Only

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• SLC4A7/NBCn1 Recombinant monoclonal antibody, PBS Only (83676-5-PBS)

• 

  WB analysis using 83676-5-RR (same clone as 83676-5-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 83676-5-RR (SLC4A7/NBCn1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83676-5-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 83676-5-RR (same clone as 83676-5-PBS)

  WB result of SLC4A7/NBCn1 antibody (83676-5-RR; 1:6000; incubated at room temperature for 1.5 hours) with sh-Control and sh-SLC4A7/NBCn1 transfected HeLa cells. This data was developed using the same antibody clone with 83676-5-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 83676-5-RR (same clone as 83676-5-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 83676-5-RR (SLC4A7/NBCn1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83676-5-PBS in a different storage buffer formulation.

SLC4A7/NBCn1 Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 83676-5-PBS

Clone No.252520E8

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

NBCn1, SLC4A7, NBC2, NBC3

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Product Information

83676-5-PBS targets SLC4A7/NBCn1 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
• Calculated Molecular Weight: 136 kDa
• Observed Molecular Weight: 150-170 kDa
• GenBank Accession Number: NM_003615
• Gene Symbol: NBCn1/SLC4A7
• Gene ID (NCBI): 9497
• RRID: AB_3743488
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q9Y6M7
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

SLC4A7 also known as NBCn1, NBC3, NBC2, is an electroneutral Na(+)/HCO(3)(-) cotransporter (PMID: 14736710). SLC4A7 mediates the coupled movement of sodium and bicarbonate ions across the plasma membrane. SLC4A7 plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (PubMed:29779931). SLC4A7 is expressed in testis, spleen, and retina. SLC4A7 may be a major regulator of extracellular pH of retina where light stimulation produces an extracellular alkalization and may contribute as a solute transporter to the prevention of retinal detachment(PMID: 9610397). The molecular weight of SLC4A7/NBCn1 detected at 150-170 kDa may be due to glycosylation modification.