Anticorps Monoclonal anti-TNFRSF9/CD137

TNFRSF9/CD137 Monoclonal Antibody for FC

Hôte / Isotype

Mouse / IgG1, kappa

Réactivité testée

Humain, primates non humains

Applications

FC

Conjugaison

Non conjugué

CloneNo.

4B4-1

N° de cat : 65159-1-Ig

Synonymes

TNFRSF9, 4 1BB, 4 1BB ligand receptor, 4-1BB ligand receptor, 4B4-1

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Galerie de données de validation

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  FC experiment of human peripheral blood mononuclear cells using 65159-1-Ig

  1X10^6 PHA stimulated (5 μg/mL, 3 days) (right) or unstimulated (left) human peripheral blood mononuclear cells (PBMCs) were surface stained with 0.13 ug Anti-Human CD137 (65159-1-Ig, Clone: 4B4-1) and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:1000. Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: cellules mononucléées de sang périphérique humain,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

65159-1-Ig cible TNFRSF9/CD137 dans les applications de FC et montre une réactivité avec des échantillons Humain, primates non humains

• Réactivité: Humain, primates non humains
• Hôte / Isotype: Mouse / IgG1, kappa
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Ectodomaine de CD137 humain recombinant
• Nom complet: tumor necrosis factor receptor superfamily, member 9
• Masse moléculaire calculée: 28 kDa
• Numéro d’acquisition GenBank: BC006196
• Symbole du gène: TNFRSF9/CD137
• Identification du gène (NCBI): 3604
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purifié par chromatographie d'affinité par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Stable for one year after shipment.

Informations générales

CD137, also known as TNFRSF9 or 4-1BB, is an inducible T cell surface receptor that belongs to the tumor necrosis factor receptor superfamily. CD137 is a transmembrane protein expressed on the surface of activated T-cells. In addition, activation-dependent expression of CD137 has also been found in B lymphocytes, monocytes, and diverse nonlymphoid cell types. CD137 provides a co-stimulatory signal that enhances the survival, and differentiation of cells, and has a crucial role in the development of CD8 cytotoxic T cells and anti-tumor immunity. (PMID: 9826581; 23696891)

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