Anticorps Polyclonal de lapin anti-Follistatin

Follistatin Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (2)

Applications

WB, IHC,ELISA

Conjugaison

Non conjugué

Publications

4

N° de cat : 10474-1-AP

Synonymes

Activin binding protein, follistatin, FS, FST

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Galerie de données de validation

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Applications testées

Dilution recommandée

Application	Dilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 1 publications below
• IHC: See 4 publications below

Informations sur le produit

10474-1-AP cible Follistatin dans les applications de WB, IHC,ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: rat, Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Follistatin Protéine recombinante Ag0775
• Nom complet: follistatin
• Masse moléculaire calculée: 33 aa, 7 kDa
• Numéro d’acquisition GenBank: BC004107
• Symbole du gène: FST
• Identification du gène (NCBI): 10468
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

Follistatin (FST) is a member of the tissue growth factor β family and is a secreted glycoprotein that antagonizes many members of the family, including activin A, growth differentiation factor11 , and myostatin. It binds activin A with high affinity and whose expression can be induced by activin A and several other pro-inflammatory cytokines. Activin A-follistatin complexes are biologically inactive and bind to cell surface heparan sulphate-containing proteoglycans for internalisation and degradation. It has also been found to play a significant role in the management of skeletal muscle size and mass. It also has important roles in early embryonic development, differentiation of ovarian granulosa cells, liver fibrosis and polycystic ovarian syndrome.

Publications

Species	Application	Title
mouse	IHC	Am J Pathol; Initial Suppression of Transforming Growth Factor-β Signaling and Loss of TGFBI Causes Early Alveolar Structural Defects Resulting in Bronchopulmonary Dysplasia.; Authors - Shawn K Ahlfeld
mouse	WB,IHC	Mol Pharm; Development of a nitric oxide-releasing analogue of the muscle relaxant guaifenesin for skeletal muscle satellite cell myogenesis.; Authors - Wang Guqi G
rat	IHC	Cell Commun Signal; Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells.; Authors - Lin Chen
human	IHC	J Int Med Res; Expression of activin A and follistatin in glioblastoma and their effects on U87 in vitro.; Authors - Zhang D F DF