Product Information
87266-1-PBS targets ZO-3 in WB, IP, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Eg5585 Product name: Recombinant human ZO3/Zonula occludens PROTEIN 3 protein Source: mammalian cells-derived, V37 Tag: C-rFc Domain: 835-919 aa of NM_001267560.1 Sequence: DEPPAPALARSSEPVQADESQSPRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYEREALKKKFMRVHDAESSDEDGYDWGPATDL Predict reactive species |
| Full Name | tight junction protein 3 (zona occludens 3) |
| Calculated Molecular Weight | 101 kDa |
| Observed Molecular Weight | 140 kDa |
| GenBank Accession Number | NM_001267560.1 |
| Gene Symbol | ZO-3 |
| Gene ID (NCBI) | 27134 |
| RRID | AB_3745435 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | O95049-1 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Tight junction (or zonula occludens) forms the continuous intercellular barrier between epithelial and endothelial cells, which is required to separate tissue spaces and regulate selective movement of solutes across the epithelium and endothelium (PMID: 20066090). ZO-3 (also known as TJP3)is a key scaffold protein of tight junctions. ZO-3 belongs to a family of multidomain proteins known as the membrane-associated guanylate kinase homologs (MAGUKs).ZO-3 regulates the stability of Cyclin D1, thereby influencing the proliferation of epithelial cells (PMID: 21411630).
