Engineering Organoids-on-a-Chip for Next-Generation Preclinical Models

Organoids-on-a-chip are emerging as next-generation preclinical models that bridge stem cell biology and microengineering.

Watch our webinar with Dr. Sunghee Estelle Park, Assistant Professor at Purdue University, as she introduces key design and biological principles underlying the integration of human organoids with microphysiological systems.

Dr. Park covered:

• How controlled microenvironments and tissue–tissue interactions drive functional maturation and disease-relevant phenotypes

• Examples from:

  • A gut organoid-on-a-chip platform for modeling the human intestinal epithelium and inflammatory bowel disease

  • A vascularized organoid-on-a-chip platform that enables host–immune interactions

  • Additional organoids-on-a-chip platforms for studying human development and disease

This workshop illustrated how organoids-on-a-chip can be designed to interrogate developmental processes, model complex pathologies, and enable translational applications in therapeutic discovery.