Tested Applications
| Positive WB detected in | mouse brain tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
25042-1-AP targets TMCC2 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag19083 Product name: Recombinant human TMCC2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-233 aa of BC131629 Sequence: MKRCRSDELQQQQGEEDGAGLEDAASHLPGADLRPGETTGANSAGGPTSDAGAAAAPNPGPRSKPPDLKKIQQLSEGSMFGHGLKHLFHSRRRSREREHQTSQDSQQHQQQQGMSDHDSPDEKERSPEMHRVSYAMSLHDLPARPTAFNRVLQQIRSRPSIKRGASLHSSSGGGSSGSSSRRTKSSSLEPQRGSPHLLRKAPQDSSLAAILHQHQCRPRSSSTTDTALLLADG Predict reactive species |
| Full Name | transmembrane and coiled-coil domain family 2 |
| Calculated Molecular Weight | 709 aa, 77 kDa |
| Observed Molecular Weight | 85-90 kDa |
| GenBank Accession Number | BC131629 |
| Gene Symbol | TMCC2 |
| Gene ID (NCBI) | 9911 |
| RRID | AB_2879866 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O75069 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
TMCC2 also termed as Cerebral protein 11 or HUCEP11 is a 709 amino acid protein, which is a multi-pass membrane protein and belongs to the TEX28 family. The TMCC2 may have an association with Alzheimer's disease.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for TMCC2 antibody 25042-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
What published studies show
The TMCC2 Polyclonal antibody (Cat# 25042-1-AP) has 3 citations. These appear in Molecular Neurodegeneration, International Journal of Molecular Sciences, and Human Molecular Genetics. The associated research fields include identification of early biomarkers for cognitive impairment in metabolically obese rats, the role of Tmcc2 gene ablation in erythropoiesis, and TMCC2 loss-induced endoplasmic reticulum stress causing auditory hair cell death. All citations used the antibody for Western blot applications.
| Species | Application | Title |
|---|---|---|
Mol Neurodegener Cognitive impairment in metabolically-obese, normal-weight rats: identification of early biomarkers in peripheral blood mononuclear cells. | ||
Hum Mol Genet Loss of TMCC2 activates endoplasm reticulum stress and causes auditory hair cell death |
