Tested Applications
| Positive FC detected in | human PBMCs |
Recommended dilution
| Application | Dilution |
|---|---|
| Flow Cytometry (FC) | FC : 5 ul per 10^6 cells in 100 μl suspension |
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
98013-2-RR targets Endoglin/CD105 in FC applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Fusion Protein Predict reactive species |
| Full Name | endoglin |
| Calculated Molecular Weight | 71 kDa |
| GenBank Accession Number | BC014271 |
| Gene Symbol | CD105 |
| Gene ID (NCBI) | 2022 |
| RRID | AB_3672156 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P17813 |
| Storage Buffer | PBS with 0.09% sodium azide, pH 7.3. |
| Storage Conditions | Store at 2 - 8°C. Stable for one year after shipment. |
Background Information
Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 90-95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodeling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)
Protocols
| Product Specific Protocols | |
|---|---|
| FC protocol for Endoglin/CD105 antibody 98013-2-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
What published studies show
The Anti-Human Endoglin/CD105 Rabbit Recombinant Antibody (241196D9), catalog number 98013-2-RR, has 3 citations. These appear in Advanced Healthcare Materials, World Journal of Stem Cells, and American Journal of Cancer Research. The associated research fields include diabetic wound healing using periodontal ligament stem cells, exosome-mediated cardiomyocyte apoptosis under oxidative stress, and interleukin-6-driven neuroblastoma progression. All cited applications are flow cytometry (FC) in human samples.
| Species | Application | Title |
|---|---|---|
Adv Healthc Mater Antioxidant MOF Nanozyme-Engineered Periodontal Ligament Stem Cells Promote Diabetic Wound Healing. | ||
World J Stem Cells Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p. | ||
Am J Cancer Res Placental mesenchymal stem cell-derived interleukin-6 promotes neuroblastoma progression |
