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Anti-Human ANTXR2 Rabbit Recombinant Antibody (98810-1-RR)

Anti-Human ANTXR2 Rabbit Recombinant Antibody

ANTXR2 Uni-rAb^® Recombinant Antibody for FC

Cat No. 98810-1-RR

Clone No.252595F1

Review Product

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

Synonyms

Anthrax toxin receptor 2, CMG 2, CMG2, CMG-2, ISH

Formulation: PBS, Azide

PBS, Azide

PBS Only

Conjugate: Unconjugated

Unconjugated

Size/Concentration:

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Filter: AllFCAffinity

FC experiment of human PBMCs using 98810-1-RR
1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human ANTXR2 Rabbit RecAb (98810-1-RR, Clone: 252595F1) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD16. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
FC experiment of human PBMCs using 98810-1-RR
1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human ANTXR2 Rabbit RecAb (98810-1-RR, Clone: 252595F1) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
Affinity of 98810-1-RR
Biolayer interferometry (BLI) kinetic assays of 98810-1-RR against Human ANTXR2 were performed. The affinity constant is below 1 pM.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

Overview

Tested Applications
Product Information
Protocols

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MSDS SDS

Tested Applications

Positive FC detected in

human PBMCs

Recommended dilution

Application	Dilution
Flow Cytometry (FC)	FC : 0.25 ug per 10^6 cells in a 100 µl suspension
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

98810-1-RR targets ANTXR2 in FC applications and shows reactivity with human samples.

Tested Reactivity	human
Host / Isotype	Rabbit / IgG
Class	Recombinant
Type	Antibody
Immunogen	CatNo: Eg7580 Product name: Recombinant Human ANTXR2 protein (rFc Tag) Source: mammalian cells-derived, V37 Tag: C-rFc Domain: 34-318 aa of NM_001145794 Sequence: QEQPSCRRAFDLYFVLDKSGSVANNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQATIILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISRSLGASVYCVGVLDFEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTYTVNETYTTSVKPVSVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNG Predict reactive species
Full Name	anthrax toxin receptor 2
Calculated Molecular Weight	54 kDa
GenBank Accession Number	NM_001145794
Gene Symbol	ANTXR2
Gene ID (NCBI)	118429
RRID	AB_3746357
Conjugate	Unconjugated
Form	Liquid
Purification Method	Protein A purification
UNIPROT ID	P58335-1
Storage Buffer	PBS with 0.09% sodium azide, pH 7.3.
Storage Conditions	Store at 2 - 8°C. Stable for one year after shipment.

Background Information

ANTXR2 (anthrax toxin receptor 2), also known as CMG2 (capillary morphogenesis gene 2 protein) is a transmembrane protein that is induced during capillary morphogenesis. It contains a vWA domain that shows strong binding to laminin and collagen IV, suggesting that this protein plays a role in basement membrane matrix assembly and endothelial cell morphogenesis (PMID: 11683410; 14508707). Like its paralog TEM8 (ANTXR1), ANTXR2 also functions as a receptor for anthrax toxin. Mutations in ANTXR2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis (PMID: 14508707; 12973667; 22383261).