FDPS Polyclonal antibody

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FDPS Polyclonal Antibody for WB, IP, ELISA

Cat No. 16129-1-AP Copied!

Publications (21)

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Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IP, ELISA

Synonyms

FDPS, FPP synthase, FPPS, FPS, KIAA1293

• 

  WB analysis using 16129-1-AP

  HepG2 cells were subjected to SDS PAGE followed by western blot with 16129-1-AP (FDPS antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  WB analysis of A431 using 16129-1-AP

  WB result of FDPS antibody (16129-1-AP; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-FDPS transfected A431 cells.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  WB analysis of rat liver using 16129-1-AP

  rat liver tissue were subjected to SDS PAGE followed by western blot with 16129-1-AP (FDPS antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  WB analysis of human cerebellum using 16129-1-AP

  human cerebellum tissue were subjected to SDS PAGE followed by western blot with 16129-1-AP (FDPS antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IP experiment of mouse liver using 16129-1-AP

  IP result of anti-FDPS (IP:16129-1-AP, 4ug; Detection:16129-1-AP 1:1000) with mouse liver tissue lysate 4000ug.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive WB detected in: HepG2 cells, A431 cells, human cerebellum tissue, rat liver tissue
• Positive IP detected in: mouse liver tissue

Recommended dilution

• Western Blot (WB): WB : 1:1000-1:5000
• Immunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

16129-1-AP targets FDPS in WB, IHC, IP, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag9115

  Product name: Recombinant human FDPS protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 68-419 aa of BC010004

  Sequence: NGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK

• Full Name: farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
• Calculated Molecular Weight: 419 aa, 48 kDa
• Observed Molecular Weight: 39-41 kDa
• GenBank Accession Number: BC010004
• Gene Symbol: FDPS
• Gene ID (NCBI): 2224
• RRID: AB_2104749
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P14324
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

FPPS (also known as FDPS) is a key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. The expression of FPPS was elevated in prostate tumor cell lines, indicating its potential role in prostate cancer progression.

Publications

What published studies show

FDPS Polyclonal antibody (Cat# 16129-1-AP) has 21 citations published in journals including Cancer Cell, Cell Metabolism, Nature Cancer, Cardiovascular Research, Cell Death & Disease, EBioMedicine, Cell Reports, JBC, and eLife. Research fields span oncology (lung, pancreatic, breast, melanoma, myeloma, hepatocellular carcinoma), cardiac hypertrophy and fibrosis, cholesterol and lipid metabolism, neurodegeneration, rheumatoid arthritis, polycystic ovary syndrome, NAFLD, ferroptosis, pyroptosis, and autophagy. Cited applications are primarily WB and IHC in human and mouse samples.

Automatically generated from the 21 publication citations by Able AI.

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
Human	WB	Cancer Cell; Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis; Authors - Wei Zhou
human	WB	Cell Metab; Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism; Authors - Xin Yang ; KD Validated
human	WB	Nat Cancer; Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer.; Authors - Chenchen Guo
mouse	WB, IHC	Cardiovasc Res; Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.; Authors - Jian Yang
mouse	WB	Cell Death Dis; Simvastatin accelerated motoneurons death in SOD1G93A mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles.; Authors - Lin Bai
human	WB	Int J Biol Sci; The SOX10-ACAT2-Cholesterol Synthesis Axis Is Required for Melanoma Proliferation.; Authors - Lihua Wang