SUR2/ABCC9 Polyclonal antibody

SUR2/ABCC9 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 13599-1-AP

Synonyms

ABC37, ABCC9, CMD1O, Sulfonylurea receptor 2, SUR2, SUR2/ABCC9

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Validation Data Gallery

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  WB analysis using 13599-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 13599-1-AP (SUR2/ABCC9 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  WB analysis using 13599-1-AP

  mouse heart were subjected to SDS PAGE followed by western blot with 13599-1-AP (SUR2/ABCC9 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: mouse heart tissue, mouse skeletal muscle tissue, unboiled mouse heart tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

13599-1-AP targets SUR2/ABCC9 in WB, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: SUR2/ABCC9 fusion protein Ag4536
• Full Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
• Calculated Molecular Weight: 1549 aa, 174 kDa
• Observed Molecular Weight: 174 kDa
• GenBank Accession Number: BC033804
• Gene Symbol: ABCC9
• Gene ID (NCBI): 10060
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

ABCC9, also known as SUR2, belongs to the ABC transporter superfamily. ABCC9 is a subunit of ATP-sensitive potassium channels (KATP), forming cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (PMID: 9831708). ABCC9 is thought to form ATP-sensitive potassium channels in cardiac, skeletal, vascular, and non-vascular smooth muscle. Defects in ABCC9 cause dilated cardiomyopathy 10 and familial atrial fibrillation type 12 (ATFB12)(PMID: 15034580,17245405).