- Featured Product
- KD/KO Validated
ACC1 Monoclonal antibody
ACC1 Monoclonal Antibody for IF, IHC, WB, ELISA
Cat no : 67373-1-Ig
|Positive WB detected in
|HeLa cells, NIH/3T3 cells, HEK-293 cells, HepG2 cells, Jurkat cells, HSC-T6 cells
|Positive IHC detected in
|human breast cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in
|Western Blot (WB)
|WB : 1:10000-1:50000
|IHC : 1:500-1:2000
|IF : 1:400-1:1600
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
67373-1-Ig targets ACC1 in WB, IHC, IF, ELISA applications and shows reactivity with Human, Mouse, Rat samples.
|Human, Mouse, Rat
|human, mouse, rat
|Host / Isotype
|Mouse / IgG2a
|ACC1 fusion protein Ag17503
|acetyl-Coenzyme A carboxylase alpha
|Calculated molecular weight
|2383 aa, 275 kDa
|Observed molecular weight
|GenBank accession number
|Gene ID (NCBI)
|Protein A purification
|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
|Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
ACACA(Acetyl-CoA carboxylase 1, ACC), also named as ACAC, ACC1 and ACCA, belongs to the biotin containing enzyme family. It catalyzes the synthesis of malonyl-CoA, which is an intermediate substrate playing a pivotal role in the regulation of fatty acid metabolism and energy production. ACACA is involved in the biosynthesis of fatty acids, and malonyl-CoA produced is used as a building block to extend the chain length of fatty acids by fatty acid synthase (FAS)(PMID:19900410). It has 4 isoforms produced by alternative promoter usage with the molecular weight between 260 kDa and 270 kDa.
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy
CARS senses cysteine deprivation to activate AMPK for cell survival.
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
Garlic-derived exosomes regulate PFKFB3 expression to relieve liver dysfunction in high-fat diet-fed mice via macrophage-hepatocyte crosstalk
Int J Mol Sci
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Parijat (Verified Customer) (09-09-2023)
Priya (Verified Customer) (06-21-2023)
Used this antibody for Caco2 cells and mice tissue