ADAM17-Specific Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 20259-1-AP

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Freight/Packing

Con: 34 μg/150 μl

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Species specificity:
human

Positive WB detected in:
human placenta tissue

Positive IHC detected in:
human pancreas cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
ADAM metallopeptidase domain 17

Calculated molecular weight:
93 kDa

Observed molecular weight:
29 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ADAM17

Synonyms
ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme
Background

The ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.


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