ADAMTS13 Recombinant antibody

• 

  WB analysis of human plasma using 85974-3-RR

  human plasma were subjected to SDS PAGE followed by western blot with 85974-3-RR (ADAMTS13 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

ADAMTS13 Uni-rAb^TM Recombinant Antibody for WB, ELISA

Cat No. 85974-3-RR

Clone No.250498E11

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

Synonyms

ADAM TS 13, ADAM TS13, ADAMTS 13, C9orf8, TTP

---

Tested Applications

• Positive WB detected in: human plasma

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

85974-3-RR targets ADAMTS13 in applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: ADAMTS13 fusion protein Eg2556
• Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 13
• Calculated Molecular Weight: 154 kDa
• Observed Molecular Weight: 180 kDa
• GenBank Accession Number: NM_139025
• Gene Symbol: ADAMTS13
• Gene ID (NCBI): 11093
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q76LX8
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 13) is a zinc-dependent metalloproteinase that contains multiple domains, such as the signal peptide, propeptide, metalloproteinase domain, disintegrin-like domain, and TSP-1 domain, among others. The primary function of ADAMTS13 is to specifically cleave the ultra-large multimers of von Willebrand factor (vWF), preventing excessive platelet aggregation and the formation of microvascular thrombi. Deficiency of ADAMTS13 is closely associated with thrombotic thrombocytopenic purpura (TTP), a severe disease characterized by thrombocytopenia, microvascular thrombosis, and tissue damage. Additionally, reduced ADAMTS13 activity is also linked to diseases such as myocardial infarction and stroke.