|Positive WB detected in||mouse liver tissue|
|Positive IP detected in||mouse liver tissue|
|Positive IHC detected in||human pancreas cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB|
|Immunohistochemistry (IHC)||IHC : 1:500-1:2000|
|Sample-dependent, check data in validation data gallery|
The immunogen of 17165-1-AP is ADH1B Fusion Protein expressed in E. coli.
|Tested Reactivity||mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||ADH1B fusion protein Ag10630|
|Full Name||alcohol dehydrogenase 1B (class I), beta polypeptide|
|Calculated molecular weight||375 aa, 40 kDa|
|Observed molecular weight||40 kDa|
|GenBank accession number||BC033009|
|Gene ID (NCBI)||125|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
The ADH1B gene encodes the beta subunit of class I alcohol dehydrogenase (ADH), an enzyme that catalyzes the rate-limiting step for ethanol metabolism: the oxidation of alcohol to acetaldehyde. Class 1 ADH is a homo- or heterodimeric molecule, formed by the association of 3 types of class I ADH subunits, alpha (ADH1A), beta, and gamma(ADH1C). ADH1B is also named as ADH2 and belongs to the zinc-containing alcohol dehydrogenase family. This protein can exsit as a homodimer(PMID:19365573).
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