AES Polyclonal antibody, PBS Only

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• AES Polyclonal antibody, PBS Only (23913-1-PBS)

• 

  WB analysis using 23913-1-AP (same clone as 23913-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 23913-1-AP (AES antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23913-1-PBS in a different storage buffer formulation.

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  WB analysis of HEK-293 using 23913-1-AP (same clone as 23913-1-PBS)

  WB result of AES antibody (23913-1-AP; 1:600; incubated at room temperature for 1.5 hours) with sh-Control and sh-AES transfected HEK-293 cells. This data was developed using the same antibody clone with 23913-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

AES Polyclonal Antibody for WB, Indirect ELISA

Cat No. 23913-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

TLE5, AES 1, AES 2, Amino-terminal enhancer of split, ESP1

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Product Information

23913-1-PBS targets AES in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag21021

  Product name: Recombinant human AES protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-81 aa of BC113735

  Sequence: MCHKNGFPQEGGITAAFLQKRKLRLSKNHRPARAKVTEHVRGTRPGRATAGPAASTRAAGSLFFDRWGNRGPAGCRGSSHL

• Full Name: amino-terminal enhancer of split
• Calculated Molecular Weight: 264 aa, 29 kDa
• Observed Molecular Weight: 22-29 kDa
• GenBank Accession Number: BC113735
• Gene Symbol: AES
• Gene ID (NCBI): 166
• RRID: AB_3669425
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen Affinity purified
• UNIPROT ID: Q08117
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Amino-terminal enhancer of split (AES), belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members in order to forcefully repress the expression of other family member genes. AES can repress NFkB-regulated gene expression and is believed to have a significant role in initiating and maintaining cell differentiation events. AES has been found to suppress local invasion and intravasation through inhibition of the Notch pathway, leading to preventing the metastatic spread of endogenous tumors(PMID: 33754069).