ALK,CD246 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60321-1-Ig |CloneNo.: 7G9E3

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Con: 240 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Recombinant protein

Positive IHC detected in:
human lymphoma tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
anaplastic lymphoma receptor tyrosine kinase

Calculated molecular weight:
1620aa,176 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ALK

Synonyms
ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK
Background

ALK, also named as CD246, is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin)-ALK oncogenic fusion protein, resulting from the (2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL). The EML4 (echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer (NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC (PMID: 17625570).


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