|Positive WB detected in||HeLa cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Sample-dependent, check data in validation data gallery|
16871-1-AP targets AMOTL1 in WB, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Full Name||angiomotin like 1|
|Calculated molecular weight||107 kDa|
|Observed molecular weight||107 kDa|
|GenBank accession number||NM_130847|
|Gene ID (NCBI)||154810|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.
Pulm Pharmacol Ther
Mitigation of tight junction protein dysfunction in lung microvascular endothelial cells with pitavastatin.
Angiomotin-like 1 plays a tumor-promoting role in glioma by enhancing the activation of YAP1 signaling.
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.