Product Information
13136-1-AP targets Anillin in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag3793 Product name: Recombinant human ANLN protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 818-1124 aa of BC034692 Sequence: VCSTVQKPDAANYYYLIILKAGAENMVATPLASTSNSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQKKDPSGLDKKKKTSKSKAITPKRLLTSITTKSNIHSSVMASPGGLSAVRTSNFALVGSYTLSLSSVGNTKFVLDKVPFLSSLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKNPIGRINLANCTSRQIEPANREFCARRNTFELITVRPQREDDRETLVSQCRDTLCVTKNWLSADTKEERDLWMQKLNQVLVDIRLWQPDACYKPIGKP Predict reactive species |
| Full Name | anillin, actin binding protein |
| Calculated Molecular Weight | 1124 aa, 124 kDa |
| GenBank Accession Number | BC034692 |
| Gene Symbol | ANLN |
| Gene ID (NCBI) | 54443 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9NQW6 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
Anillin, an actin-binding protein, is a conserved cleavage furrow component important for cytokinesis. The human anillin protein localizes to the nucleus during interphase, the cortex following nuclear envelope breakdown, and the cleavage furrow during cytokinesis. It interactions with at least two other furrow proteins, actin and the septins through its C-terminal PH domain and N-terminal actin-binding domain. In anillin knockdown cells, the cleavage furrow ingressed but failed to complete the ingression. Anillin has been found to be overexpressed in tumors and may serve as promising marker for pancreatic carcinoma molecular diagnostics as well as a prognostic indicator for non–small cell lung cancers.
Publications
What published studies show
The Anillin Polyclonal antibody (Cat# 13136-1-AP) has 1 total citation. It appears in Molecular and Cellular Biochemistry, where it was used in WB and IHC to study ANLN knockdown effects on cell growth and migration in human breast cancer. The associated research field is oncology, specifically breast cancer biology and cytokinesis regulation.
| Species | Application | Title |
|---|---|---|
Mol Cell Biochem Knockdown of ANLN by lentivirus inhibits cell growth and migration in human breast cancer.
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