|Positive ELISA detected in||peptide|
|Enzyme-linked Immunosorbent Assay (ELISA)||ELISA : 1:10-1:100|
|Sample-dependent, check data in validation data gallery|
24493-1-AP targets AP repeat in WB, IHC, IF,ELISA applications and shows reactivity with human samples.
The C9orf72 "GGGGCC" repeat sequence codes five repeat peptide "GA repeat; GAGAGAGAGA", "GP repeat; GPGPGPGPG", "GR repeat; GRGRGRGRG", "AP repeat; APAPAPAPA" and "PR repeat; PRPRPRPRP". It was described previously that aggregated forms of poly-GA and poly-GP proteins do not enter the separation gel (PMID: 26374446). This antibody is used to detect the "AP repeat" sequence. This antibody detects the APAPAPAPA peptide with dilution 1:32,000 in Elisa.
J Cell Sci
SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72.
Hum Mol Genet
Modelling C9orf72 dipeptide repeat proteins of a physiologically relevant size.
Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy.
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.
Increased prevalence of granulovacuolar degeneration in C9orf72 mutation.