ARFGAP1 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 13571-1-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 62 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat

Positive WB detected in:
PC-3 cells, HeLa cells, human brain tissue

Positive IP detected in:
mouse testis tissue

Positive IHC detected in:
human prostate cancer tissue

Positive IF detected in:
PC-3 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ADP-ribosylation factor GTPase activating protein 1

Calculated molecular weight:
414aa,46 kDa

Observed molecular weight:
46 kDa, 50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ARFGAP1

Synonyms
ARF GAP 1, ARF1 GAP, ARF1GAP, ARFGAP1, HRIHFB2281
Background

Protein coats deform flat lipid membranes into buds and capture membrane proteins to form transport vesicles. The assembly-disassembly cycle of the COPI coat on Golgi membranes is coupled to the GTP-GDP cycle of the small G protein ARF1. ARFGAP1 contributes to vesicle budding by increasing the GTPase activity of ARF1, because it promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. for ARFGAP1 may has a role in regulating the GTPase activity and neuronal toxicity of LRRK2; reciprocally, LRRK2 phosphorylates ArfGAP1 and is required for ArfGAP1 neuronal toxicity.


Back
to top