ARMC12 Polyclonal antibody

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• ARMC12 Polyclonal antibody (33045-1-AP)

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  WB analysis using 33045-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 33045-1-AP (C6orf81 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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  IP experiment of mouse testis using 33045-1-AP

  IP result of anti-C6orf81 (IP:33045-1-AP, 4ug; Detection:33045-1-AP 1:1000) with mouse testis tissue lysate 1680 ug.

ARMC12 Polyclonal Antibody for WB, IP, ELISA

Cat No. 33045-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IP, ELISA

Synonyms

Armadillo Repeat Containing 12, Armadillo repeat-containing protein 12, C6orf81

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Tested Applications

• Positive WB detected in: mouse testis tissue
• Positive IP detected in: mouse testis tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000
• Immunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

33045-1-AP targets ARMC12 in WB, IP, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag37979

  Product name: Recombinant human C6orf81 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-367 aa of BC033033

  Sequence: MGKSIPQYLGQLDIRKSVVSLATGAGAIYLLYKAIKAGIKCKPPLCSNSPICIARECPGPGERALPQEAPAPEASAVGGPKGLAVERERHGRDSGELRRLLNSLECKQDEYAKSMILHSITRCVYLLEAEASACTTDDIVLLGYMLDDKDNSVKTQALNTLKAFSGIRKFRLKIQEHSIKVLELISTIWDTELHIAGLRLLNNLPLPDYVHPQLRRVMPALMEILQSDYILAQVQAVRLLSYLAQKNDLLYDILNCQVHSNFLNLFQPTQSGSLLYEVLVFAERLSEGRNAPHYHVVKWHYNEQSLHESLFGEESRLADRLLALVIHPEEDVQIQACKVIVSLQYPQDLRARPSSCQPSRSYFKNTE

• Full Name: chromosome 6 open reading frame 81
• Observed Molecular Weight: 37 kDa
• GenBank Accession Number: BC033033
• Gene Symbol: C6orf81
• Gene ID (NCBI): 221481
• RRID: AB_3742834
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q5T9G4
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

ARMC12 (Armadillo Repeat Containing 12) is a protein localized to the outer mitochondrial membrane and belongs to the protein family containing Armadillo repeat sequences. Its primary function is to act as a positive regulator of mitochondrial fission. Research indicates that ARMC12 interacts with core proteins involved in mitochondrial fission, such as the dynamin-related protein DRP1 and its receptor MFF, facilitating the proper assembly and localization of the mitochondrial fission complex on the mitochondrial surface, thereby precisely regulating the fission process. Mitochondrial fission is crucial for maintaining mitochondrial network homeostasis, energy metabolism, apoptosis, and autophagy. Consequently, dysfunction of ARMC12 is believed to be potentially associated with diseases related to abnormal mitochondrial morphology, such as neurodegenerative diseases, metabolic disorders, and cancer, making it an important subject of study in the field of mitochondrial dynamics.