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- KD/KO Validated
Beta Arrestin 2 Polyclonal antibody
Beta Arrestin 2 Polyclonal Antibody for IF, IHC, WB, ELISA
Host / Isotype
Rabbit / IgG
human, mouse, rat and More (1)
WB, IP, IHC, IF, ELISA
Cat no : 10171-1-AP
Validation Data Gallery
|Positive WB detected in||mouse brain tissue, RAW264.7, PC-12 cells, rat brain tissue|
|Positive IHC detected in||human tonsil tissue, human malignant melanoma tissue, human colon cancer tissue, human spleen tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||mouse Retina tissue|
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Immunofluorescence (IF)||IF : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
|KD/KO||See 5 publications below|
|WB||See 14 publications below|
|IHC||See 3 publications below|
|IF||See 5 publications below|
|IP||See 1 publications below|
10171-1-AP targets Beta Arrestin 2 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse, rat, Xenopus|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Beta Arrestin 2 fusion protein Ag0227|
|Full Name||arrestin, beta 2|
|Calculated molecular weight||46 kDa|
|Observed molecular weight||50 kDa|
|GenBank accession number||BC007427|
|Gene ID (NCBI)||409|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
Beta Arrestin 2 is a member of arrestin/beta-arrestin protein family, which are expressed at high levels in the central nervous system (CNS) and play a critical role in the regulation of G-protein coupled receptors (GPCRs) including MOR. Beta Arrestin 2 is an adaptor protein that is important for the regulation of receptors belonging to both dopaminergic and opioid systems. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors.
|Product Specific Protocols|
|WB protocol for Beta Arrestin 2 antibody 10171-1-AP||Download protocol|
|IHC protocol for Beta Arrestin 2 antibody 10171-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation.
Autophagy and post-ischemic conditioning in retinal ischemia.
J Cell Biol
BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone.
The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning.
Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence.
Cell Death Dis
β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.