|Sample-dependent, check data in validation data gallery|
12301-1-AP targets ASCC1 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||ASCC1 fusion protein Ag2946|
|Full Name||activating signal cointegrator 1 complex subunit 1|
|Calculated molecular weight||45.5 kDa|
|Observed molecular weight||45.5 kDa|
|GenBank accession number||BC012291|
|Gene ID (NCBI)||51008|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
ASCC1 (also known as p50) is a subunit of an uncharacterized complex, the activating signal co-integrator complex (ASCC). ASCC1 has been reported as regulator fo NF-kB pathway and potently inhibits the expression of NF-kB target genes. Mutations in ASCC1 in patients with Barrett esophagus (BE) have been identified as a risk factor of esophageal adenocarcinoma (EAC).
Extended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex
Translation stress and collided ribosomes are co-activators of cGAS.
Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress.