BCL3 Recombinant antibody, PBS Only

BCL3 Uni-rAbTM Recombinant Antibody for IHC, IF/ICC, Indirect ELISA

Cat No. 84882-5-PBS
Clone No.242233B11

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IHC, IF/ICC, Indirect ELISA

242233B11, B-cell lymphoma 3 protein, BCL-3, BCL4, D19S37

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

Please visit your regions distributor:


Product Information

84882-5-PBS targets BCL3 in IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen BCL3 fusion protein Ag13375 Predict reactive species
Full Name B-cell CLL/lymphoma 3
Calculated Molecular Weight 446 aa, 47 kDa
Observed Molecular Weight 48-60 kDa
GenBank Accession NumberBC064993
Gene Symbol BCL3
Gene ID (NCBI) 602
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP20749
Storage Buffer PBS only, pH 7.3.
Storage ConditionsStore at -80°C.

Background Information

BCL3 (B-cell lymphoma 3 protein) has seven ankyrin repeat domains, a proline-rich N terminal domain and a serine- and proline-rich C-terminal domain (PMID: 31930327). BCL3 is an important contributor to chronic inflammatory disease states, such as osteoarthritis and rheumatoid arthritis (PMID: 12483727). BCL3 is a predominantly nuclear protein containing a trans-activation domain, and it can be recruited to NF-κB-responsive promoters, resulting in transcriptional activation or repression depending on the subunit composition of NF-κB complexes (PMID: 25089799, PMID: 30135206). BCL3 is known to be overexpressed in human breast cancers and is associated with reduced metastasis-free survival (PMID: 38255248).

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