BCO2 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 14324-1-AP

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Con: 25 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
L02 cells, human liver tissue, mouse liver tissue

Positive IHC detected in:
human liver cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
beta-carotene oxygenase 2

Calculated molecular weight:
66 kDa

Observed molecular weight:
60-65kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BCO2

Synonyms
B DIOX II, BCO2, Beta carotene dioxygenase 2, beta carotene oxygenase 2, FLJ34464
Background

Beta,beta-carotene 9',10'-oxygenase (BCO2) catalyzes the asymmetric oxidative cleavage of beta-carotene in carotene metabolism.The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. BCDO2 plays an important role in protecting against carotenoid-induced mitochondrial dysfunction and has a broader substrate specificity than previously recognized(PMID:22147584). This antibody detects the N-terminal of BCO2.


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