BLOC1S1-Specific Polyclonal antibody

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BLOC1S1-Specific Polyclonal Antibody for WB, IP, ELISA

Cat No. 19687-1-AP Copied!

Publications (11)

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Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF, IP, ELISA

Synonyms

BLOC1S1, Biogenesis of lysosome-related organelles complex 1 subunit 1, BLOC 1 subunit 1, BLOC-1 subunit 1, BLOS1

• 

  WB analysis of human brain using 19687-1-AP

  human brain tissue were subjected to SDS PAGE followed by western blot with 19687-1-AP (BLOC1S1-Specific antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  WB analysis of RAW 264.7 using 19687-1-AP

  WB result of BLOC1S1-Specific antibody (19687-1-AP; 1:400; incubated at room temperature for 1.5 hours) with sh-Control and sh-BLOC1S1-Specific transfected RAW 264.7 cells.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  WB analysis of rat brain using 19687-1-AP

  rat brain tissue were subjected to SDS PAGE followed by western blot with 19687-1-AP (BLOC1S1-Specific antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  WB analysis of mouse brain using 19687-1-AP

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 19687-1-AP (BLOC1S1-Specific antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IP experiment of mouse brain using 19687-1-AP

  IP result of anti-BLOC1S1-Specific (IP:19687-1-AP, 3ug; Detection:19687-1-AP 1:1000) with mouse brain tissue lysate 4000ug.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive WB detected in: human brain tissue, mouse brain tissue, rat brain tissue, RAW 264.7 cells
• Positive IP detected in: mouse brain tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000
• Immunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

19687-1-AP targets BLOC1S1-Specific in WB, IHC, IF, IP, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: biogenesis of lysosomal organelles complex-1, subunit 1
• Calculated Molecular Weight: 17 kDa
• Observed Molecular Weight: 14-17 kDa
• GenBank Accession Number: NM_001487
• Gene Symbol: BLOC1S1
• Gene ID (NCBI): 2647
• RRID: AB_10666440
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P78537
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

BLOC1S1, also named as BLOS1, GCN5L1 and RT14, belongs to the BLOC1S1 family. BLOC1S1 may be involved in the biogenesis of specialized organelles of the endosomal-lysosomal system. The antibody is specific to BLOC1S1.

Publications

What published studies show

The GCN5L1 antibody (catalog no. 19687-1-AP) has 11 citations published in journals including Nature Communications, EMBO Journal, Circulation Research, Molecular Therapy, Autophagy, Molecular Medicine, Oxidative Medicine and Cellular Longevity, Molecular & Cellular Proteomics, Journal of Physiology and Biochemistry, FEBS Journal, and BMC Pregnancy and Childbirth. Associated research fields span neurodegeneration, ER stress, mitochondrial dysfunction, cardiovascular disease, ALS, diabetic nephropathy, oxidative stress, lipotoxicity, and cholestasis.

Automatically generated from the 11 publication citations by Able AI.

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
human	WB	Autophagy; HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons.; Authors - Maryline Santerre
human	WB	Nat Commun; Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α; Authors - Adrien Le Thomas
mouse	WB	Circ Res; NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction.; Authors - Dan Tong
human, mouse	WB	Mol Ther; BLOC1S1 depletion via splice-switching oligonucleotides improves mitochondrial respiration and rescues ALS phenotypes.; Authors - Jin-Hui Hor
human	WB	EMBO J; Snapin promotes HIV-1 transmission from dendritic cells by dampening TLR8 signaling.; Authors - Elham Khatamzas
mouse	WB,IP,IHC,IF	Mol Med; Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes cerebral ischemic injury via facilitating mitochondrial fission; Authors - Jiejie Zhang