BNIP1 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 15964-1-AP

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Freight/Packing

Con: 31 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, HeLa cells, human liver tissue, mouse skeletal muscle tissue, rat brain tissue

Positive IP detected in:
mouse brain tissue

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
BCL2/adenovirus E1B 19kDa interacting protein 1

Calculated molecular weight:
228aa,26 kDa

Observed molecular weight:
26 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BNIP1

Synonyms
BNIP1, NIP1, SEC20, SEC20L, TRG 8
Background

BNIP1 is a member of the BCL2/adenovirus E1B 19 kDa-interacting protein (BNIP) family. The encoded protein is predominantly localized to the endoplasmic reticulum (ER), is a pro-apoptotic Bcl-2 homology domain 3 (BH3)-only protein. BNIP1, also called SEC20L, is a component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B which is involved in apoptosis and ER membrane fusion. Recent reports showed that expression of BNIP1 induced mitochondrial fragmentation in a BH3 domain-dependent manner via increasing dynamin-related protein 1 (Drp1) expression. RNF185 is a mitochondrial ubiquitin E3 ligase that regulates selective mitochondrial autophagy, BNIP1 colocalizes with RNF185 at mitochondria and is polyubiquitinated by RNF185 through K63-based ubiquitin linkage in vivo and modulatemitochondrial homeostasis through autophagy.


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