BRE Polyclonal antibody, PBS Only

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• BRE Polyclonal antibody, PBS Only (11702-1-PBS)

• 

  WB analysis using 11702-1-AP (same clone as 11702-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 11702-1-AP (BRE antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11702-1-PBS in a different storage buffer formulation.

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  IP experiment of HeLa using 11702-1-AP (same clone as 11702-1-PBS)

  IP result of anti-BRE (IP:11702-1-AP, 4ug; Detection:11702-1-AP 1:1000) with HeLa cells lysate 2320 ug. This data was developed using the same antibody clone with 11702-1-PBS in a different storage buffer formulation.

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  IHC staining of human gliomas using 11702-1-AP (same clone as 11702-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 11702-1-AP (BRE antibody) at dilution of 1:100 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11702-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human gliomas using 11702-1-AP (same clone as 11702-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 11702-1-AP (BRE antibody) at dilution of 1:100 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11702-1-PBS in a different storage buffer formulation.

BRE Polyclonal Antibody for WB, IHC, IP, Indirect ELISA

Cat No. 11702-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, IP, Indirect ELISA

Synonyms

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Product Information

11702-1-PBS targets BRE in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag2256

  Product name: Recombinant human BRE protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 94-383 aa of BC001251

  Sequence: PDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL

• Full Name: brain and reproductive organ-expressed (TNFRSF1A modulator)
• Calculated Molecular Weight: 383 aa, 44 kDa
• Observed Molecular Weight: 40-44 kDa
• GenBank Accession Number: BC001251
• Gene Symbol: BRE
• Gene ID (NCBI): 9577
• RRID: AB_2066049
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9NXR7
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

BRE, also named as BRCC45, is a death receptor-associated antiapoptotic protein, which is also involved in DNA-damage repair, and K63-specific deubiquitination. BRE and its XIAP-sustaining mechanism could represent novel targets for anti-cancer therapy. BRE may regulate TNF-alpha signaling through its interactions with TNFRSF1A. It plays a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. BRE gene has four isoforms with MW 42-47 kDa.