CD147 Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 11989-1-AP

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Freight/Packing

Con: 48 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
human liver tissue, Jurkat cells, mouse heart tissue, mouse liver tissue

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human lung cancer tissue, human breast cancer tissue, human gliomas tissue, human liver cancer tissue

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
basigin (Ok blood group)

Calculated molecular weight:
385aa,42 kDa

Observed molecular weight:
42-50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BSG

Synonyms
5F7, Basigin, basigin (Ok blood group), BSG, CD147, Collagenase stimulatory factor, EMMPRIN, HAb18G, M6, OK, OK blood group antigen, TCSF
Background

BSG, also named as 5F7, Basigin, EMMPRIN, TCSF and CD147, plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS).CD147 may target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. It seems to be a receptor for oligomannosidic glycans. CD147 is a receptor of CypA, inducing matrix metalloproteinase expression and mediating the degradation of the extracellular matrix, plays an important role in tumorigenesis and invasion in oral cancer. It has been considered as an objective and effective marker to predict invasion and prognosis in various cancers.


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