Anti-Human BST2 Rabbit Recombinant Antibody, PBS Only

• 

  FC experiment of human PBMCs using 98305-2-RR (same clone as 98305-2-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human BST2 Rabbit RecAb (98305-2-RR, Clone: 250317H5) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD14. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98305-2-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98305-2-RR (same clone as 98305-2-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human BST2 Rabbit RecAb (98305-2-RR, Clone: 250317H5) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98305-2-PBS in a different storage buffer formulation.

BST2 Uni-rAb^TM Recombinant Antibody for FC

Cat No. 98305-2-PBS

Clone No.250317H5

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

CD317, Bone marrow stromal antigen 2, BST 2, BST-2, CD 317

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Product Information

98305-2-PBS targets BST2 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: BST2 fusion protein Eg1961
• Full Name: bone marrow stromal cell antigen 2
• Calculated Molecular Weight: 180 aa, 20 kDa
• GenBank Accession Number: BC033873
• Gene Symbol: BST2
• Gene ID (NCBI): 684
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q10589
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

BST2, also named as CD317 and Tetherin, belongs to the tetherin family. It may be involved in the sorting of secreted proteins and it is involved in pre-B-cell growth. BST2 is an antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. BST2 may play a role in B-cell activation in rheumatoid arthritis. It is recently identified interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. BST2 is a plasma membrane proteins, tetherin inhibits virion particle release from infected cells. BST2 is effective against retroviruses and flavoviruses whilst IFITMs disrupt influenza and flavivirus infection. Observed MW of BST2 is 30-36 kDa (PMID: 19196977; 21237475).