BZRAP1 Polyclonal antibody

BZRAP1 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human, mouse

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 28241-1-AP

Synonyms

BZRAP1, DKFZp686F02123, KIAA0612, PBR IP, PRAX 1, PRAX1, RBP1, RIM BP1, RIMBP1, RIMS binding protein 1

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Validation Data Gallery

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  WB analysis of Neuro-2a using 28241-1-AP

  Neuro-2a cells were subjected to SDS PAGE followed by western blot with 28241-1-AP (BZRAP1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: Neuro-2a cells

Recommended dilution

• Western Blot (WB): WB : 1:200-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

28241-1-AP targets BZRAP1 in WB, ELISA applications and shows reactivity with Human, mouse samples.

• Tested Reactivity: Human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: BZRAP1 fusion protein Ag28198
• Full Name: benzodiazapine receptor (peripheral) associated protein 1
• Calculated Molecular Weight: 1857 aa, 200 kDa
• Observed Molecular Weight: 200-235 kDa
• GenBank Accession Number: BC146852
• Gene Symbol: BZRAP1
• Gene ID (NCBI): 9256
• RRID: AB_2881096
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

BZRAP1, also named as TSPOAP1 and PBR-associated protein 1 (PRAX-1), is a cytoplasmic protein of 1857 residues. It plays a key role in inflammation, neuroinflammation, mental and metabolic diseases, and cancer. BZRAP1 predominantly expressed in the central nervous system, pituitary gland, and thymus, specially abundant in the CA1 subfield of the hippocampus. Tumor necrosis factor receptor 1 (TNFR1), vascular cell adhesion molecule 1 (VCAM1), cyclic AMP response element-binding protein 1 (CREB1), T-cell receptor (TCR), nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain containing 3 (NLRP3), DNA-dependent protein kinase (DNA-PK or PRKDC), and mitochondrial permeability transition pore (mPTP) were the major interaction partners of BZRAP1 (PMID: 34212002).