C20orf20 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 26040-1-AP

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Freight/Packing

Con: 43 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HepG2 cells, mouse testis tissue

Positive IP detected in:
HepG2 cells

Positive IHC detected in:
human colon cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
chromosome 20 open reading frame 20

Calculated molecular weight:
204aa,22 kDa

Observed molecular weight:
30 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
C20orf20

Synonyms
C20orf20, Eaf7, FLJ10914, MRG binding protein, MRG15BP, MRGBP, URCC4
Background

C20orf20, also named as MRG/MORF4L-binding protein or Up-regulated in colon cancer 4 (Urcc4), is a 204 amino acid protein, which belongs to the EAF7 family. C20orf20 localizes in the nucleus and is a Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. C20orf20 is modified through phosphorylation and acetylation, so the molecular weight of C20orf20 might be 25-30 kDa.


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