C4orf32 Polyclonal antibody

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• C4orf32 Polyclonal antibody (33453-1-AP)

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  WB analysis using 33453-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 33453-1-AP (C4orf32 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

C4orf32 Polyclonal Antibody for WB, ELISA

Cat No. 33453-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

FAM241A, Family With Sequence Similarity 241 Member A, Uncharacterized protein FAM241A

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Tested Applications

• Positive WB detected in: human placenta tissue

Recommended dilution

• Western Blot (WB): WB : 1:1000-1:6000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

33453-1-AP targets C4orf32 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag38764

  Product name: Recombinant human C4orf32 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-99 aa of BC022534

  Sequence: MCSAGELLRGGDGGERDEDGDALAEREAAGTEWDPGASQRRRGQRQKESEQDVEDSQNHTGEPVGDDYKKMGTLFGELNKNLINMGFTRMYFGERIVEP

• Full Name: chromosome 4 open reading frame 32
• Observed Molecular Weight: 20 kDa
• GenBank Accession Number: BC022534
• Gene Symbol: C4orf32
• Gene ID (NCBI): 132720
• RRID: AB_3742977
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q8N8J7
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

The FAM241A protein, also known as C4orf32, is a key regulatory factor that is localized to the Golgi apparatus. It plays an important role in maintaining the structural integrity of the Golgi apparatus and is involved in processes such as protein glycosylation and vesicle transport. More importantly, FAM241A has been identified as a novel negative regulator of the Hippo signaling pathway. It directly binds to and inhibits the activity of the core kinases MST1/2, thereby relieving the suppression of the downstream effectors YAP/TAZ, promoting cell proliferation, and inhibiting apoptosis. Aberrant function of FAM241A is closely related to the occurrence and development of various human diseases, especially tumors, making it a highly promising target for basic research and clinical translation.