CA8 Recombinant antibody, PBS Only

CA8 Uni-rAbTM Recombinant Antibody for IHC, Indirect ELISA
Cat No. 86004-1-PBS
Clone No.250429B8

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IHC, Indirect ELISA

carbonic anhydrase VIII, CA 8, CA VIII, CALS, Carbonic anhydrase-related protein

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

Please visit your regions distributor:


Product Information

86004-1-PBS targets CA8 in IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen CA8 fusion protein Ag3068 Predict reactive species
Full Name carbonic anhydrase VIII
Calculated Molecular Weight 290 aa, 32 kDa
GenBank Accession NumberBC015531
Gene Symbol CA8
Gene ID (NCBI) 767
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP35219
Storage Buffer PBS only, pH 7.3.
Storage ConditionsStore at -80°C.

Background Information

The CA8 (CARP) gene encodes carbonic anhydrase VIII, which is part of a family of zinc metalloenzyme. CA8 has a central carbonic anhydrase motif, but it lacks carbonic anhydrase activity due to absence of catalytic zinc coordinating residues(PMID:2121526). CARP is a novel IP3R1-binding protein, and is expressed in Purkinje cells abundantly. CA8 is co-localized with IP3R1 in Purkinje cells and it binds to IP3R1, reducing the affinity of the receptor for its ligand, IP3(PMID:12611586). Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3)(PMID:19461874).

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