CACNA1H Polyclonal antibody

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  WB analysis using 28092-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 28092-1-AP (CACNA1H antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

CACNA1H Polyclonal Antibody for WB, ELISA

Cat No. 28092-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

CACNA1HB, Cav3.2, EIG6, FLJ90484, Low-voltage-activated calcium channel alpha1 3.2 subunit

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Tested Applications

• Positive WB detected in: HeLa cells

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

28092-1-AP targets CACNA1H in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: CACNA1H fusion protein Ag26094
• Full Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
• Calculated Molecular Weight: 259 kDa
• Observed Molecular Weight: 259 kDa
• GenBank Accession Number: NM_001005407
• Gene Symbol: CACNA1H
• Gene ID (NCBI): 8912
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O95180
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H) is located in the plasma membrane of various tissues, including the brain cortex, amygdala, caudate nucleus, putamen, kidney, liver, and heart. This subunit regulates muscle contraction, secretion, neurotransmission, and gene expression by forming the pore (PMID: 33985586). Predominantly, the changes observed are missense mutations associated with gain-of-function, resulting in an increased influx of calcium into adrenal cells (PMID: 33985586; 37311830).