CAMSAP1 Polyclonal antibody

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  WB analysis using 18816-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 18816-1-AP (CAMSAP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

CAMSAP1 Polyclonal Antibody for WB, ELISA

Cat No. 18816-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Synonyms

PRO2405, Calmodulin-regulated spectrin-associated protein 1

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Tested Applications

• Positive WB detected in: SH-SY5Y cells, mouse brain tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

18816-1-AP targets CAMSAP1 in WB, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: calmodulin regulated spectrin-associated protein 1
• Calculated Molecular Weight: 179 kDa
• Observed Molecular Weight: 245 kDa
• GenBank Accession Number: BC144082
• Gene Symbol: CAMSAP1
• Gene ID (NCBI): 157922
• RRID: AB_3669303
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q5T5Y3
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

CAMSAP1, or Calmodulin-regulated spectrin-associated protein 1, is a protein that plays a crucial role in the formation and maintenance of the minus end of non-centrosomal microtubules, which are essential for proper neuronal function and development. Research has shown that CAMSAP1 is vital for neuronal polarization, migration, and cortical lamination. CAMSAP1 has also been implicated in cancer prognosis. A study found that CAMSAP1 mutation can activate anti-tumor immunity, mediate tumor cell apoptosis, inhibit epithelial-mesenchymal transition (EMT), improve prognosis, and improve platinum drug sensitivity in small-cell lung cancer patients treated with platinum-based chemotherapy, suggesting that CAMSAP1 mutation may be a potential biomarker indicating platinum drug sensitivity and patient prognosis. The CAMSAP1 of the calculated MW is around 170 kDa, and the observed MW is 245 kDa (PMID: 32839317).