Caspase 7/p20/p11 Polyclonal antibody

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Caspase 7/p20/p11 Polyclonal Antibody for ELISA

Cat No. 10459-1-AP

Publications(5)

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat and More (1)

Applications

WB, ELISA

Synonyms

Apoptotic protease Mch 3, CASP 7, CASP7, Caspase 7, Caspase 7/p20/p11, Caspase7, CMH 1, ICE LAP3, ICE like apoptotic protease 3, MCH3

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Published Applications

• WB: See 5 publications below

Product Information

10459-1-AP targets Caspase 7/p20/p11 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: human, mouse, bovine
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Caspase 7/p20/p11 fusion protein Ag0670
• Full Name: caspase 7, apoptosis-related cysteine peptidase
• Calculated Molecular Weight: 303 aa, 34 kDa
• GenBank Accession Number: BC015799
• Gene Symbol: Caspase 7
• Gene ID (NCBI): 840
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P55210
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Caspase 7(CASP7), like caspases 3 and 6, contains a short prodomain and, upon apoptotic induction, the 35 kDa proform is converted into a 32 kDa intermediate or preactive form which is further processed into two active subunits consisting of the p20 or large (18 kDa) subunit and the p10 or small (11 kDa) subunit and it is present in the brain, which is up-regulated and activated after traumatic injury(PMID:15953353). Caspase-7 is classified as a member of the subgroup of cysteine proteases most related to the Caenorhabditis elegans factor CED-3, which also includes caspase-3, -6, and -9(PMID:9426061). The protein is involved in the activation cascade of caspases responsible for apoptosis execution.

Publications

Species	Application	Title
human	WB	Ann Transl Med; Molecular mechanism of the miR-7/BCL2L1/P53 signaling axis regulating the progression of hepatocellular carcinoma; Authors - Nannan Zhang
human	WB	J Pharm Pharmacol; Maackiain suppresses the development of cervical cancer via AMPK priming autophagy; Authors - Juan He
human	WB	J Bone Oncol; Mometasone furoate inhibits tumor progression and promotes apoptosis through activation of the AMPK/mTOR signaling pathway in osteosarcoma; Authors - Zhaohui Li
mouse,bovine	WB	Biomolecules; Activation of ARP2/3 and HSP70 Expression by Lipoteichoic Acid: Potential Bidirectional Regulation of Apoptosis in a Mastitis Inflammation Model; Authors - Bo Fang
human	WB	Phytother Res; Agrimoniin is a dual inhibitor of AKT and ERK pathways that inhibit pancreatic cancer cell proliferation; Authors - Xiongfei Zhang