|Positive WB detected in||HEK-293 cells, A431 cells, HeLa cells, human brain tissue|
|Positive IP detected in||HEK-293 cells|
|Positive IF detected in||HEK-293 cells|
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
10241-2-AP targets CBX1 in WB, IP, IHC, IF,ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||CBX1 fusion protein Ag0328|
|Full Name||chromobox homolog 1 (HP1 beta homolog Drosophila )|
|Calculated molecular weight||27 kDa|
|Observed molecular weight||27 kDa|
|GenBank accession number||BC002609|
|Gene ID (NCBI)||10951|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
One function of heterochromatin is the epigenetic silencing by sequestration of genes into transcriptionally repressed nuclear neighborhoods. Heterochromatin protein 1 (HP1) is a major component of heterochromatin and is a candidate for establishing and mediating gene silencing. This protein is expressed in all adult and embryonic tissues, as a homodimer.
PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.
J Cell Biol
Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins.
The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.