Validation Data Gallery
|Positive WB detected in||A431 cells, MCF-7 cells, HEK-293 cells, human brain tissue, NIH/3T3 cells|
|Positive IP detected in||HEK-293 cells|
|Positive IF detected in||HEK-293 cells|
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
10241-2-AP targets CBX1 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||CBX1 fusion protein Ag0328|
|Full Name||chromobox homolog 1 (HP1 beta homolog Drosophila )|
|Calculated molecular weight||27 kDa|
|Observed molecular weight||27 kDa|
|GenBank accession number||BC002609|
|Gene ID (NCBI)||10951|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
One function of heterochromatin is the epigenetic silencing by sequestration of genes into transcriptionally repressed nuclear neighborhoods. Heterochromatin protein 1 (HP1) is a major component of heterochromatin and is a candidate for establishing and mediating gene silencing. This protein is expressed in all adult and embryonic tissues, as a homodimer.
J Exp Med
ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.
The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.
J Cell Biol
Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins.
PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.
Identification and Validation of Chromobox Family Members as Potential Prognostic Biomarkers and Therapeutic Targets for Human Esophageal Cancer.
Adv Sci (Weinh)
N6 -Methyladenosine-Modified CBX1 Regulates Nasopharyngeal Carcinoma Progression Through Heterochromatin Formation and STAT1 Activation
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WEI (Verified Customer) (03-08-2022)
Band at predicted size