|Positive WB detected in||BxPC-3 cells, human stomach tissue, SGC-7901 cells|
|Positive IF detected in||BxPC-3 cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Immunofluorescence (IF)||IF : 1:10-1:100|
|Sample-dependent, check data in validation data gallery|
16549-1-AP targets CCKBR-specific in WB, IHC, IF,ELISA applications and shows reactivity with human samples.
|Host / Isotype||Rabbit / IgG|
|Full Name||cholecystokinin B receptor|
|Calculated molecular weight||56 kDa|
|Observed molecular weight||64 kDa, 50 kDa|
|GenBank accession number||NM_176875|
|Gene ID (NCBI)||887|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
The cholecystokinin B receptor (CCKBR) is a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.
J Cancer Res Clin Oncol
Cholecystokinin type 2 receptor in colorectal cancer: diagnostic and therapeutic target.
Pseudomonas Exotoxin A-Based Immunotherapy Targeting CCK2R-Expressing Colorectal Malignancies: An In Vitro and In Vivo Evaluation.